CHARACTERISATION OF SHIGELLA SPECIES ISOLATED FROM RIVER CATCHMENTS IN THE NORTH WEST PROVINCE OF SOUTH AFRICA

Characterisation of Shigella species isolated from river catchments in the North West province of South Africa

The occurrence and distribution of Shigella species in water from the five river catchments in the North West province of South Africa were investigated.Shigella is a Gram-negative, non-motile, facultative anaerobic bacillus that causes shigellosis, an important cause of morbidity and mortality in high-risk populations (such as children, the elderl

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Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks.The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP) contributes to significant cytotoxicity in inflammation of various etiolo

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